Quantum uplinks to Earth-orbiting satellites will necessitate single-photon detector technology that is robust to space radiation for the lifetime of the satellite. In this study, we experimentally assessed the effect of such radiation on a targetted selection of candidate detectors, with a focus on their impact to quantum key distribution. We then attempted to mitigate these effects, using thermal controls including deep cooling (during operation) and high-temperature annealing. Our results show that such techniques can maintain useful performance significantly beyond the one-year baseline lifetime.